Introduction

The 49ers vs Los Angeles Rams matchup has become the NFL’s most electric divisional rivalry. In 2025, these two teams split their regular-season series in dramatic fashion. The 49ers won 26-23 in overtime in Week 5, while the Rams answered with a dominant 42-26 victory in Week 10. This pillar page delivers the full 49ers vs Los Angeles Rams match player stats, game-changing moments, and top performers from every angle.

What Makes the 49ers vs Los Angeles Rams Rivalry So Special?

The 49ers and Rams have battled since 1950, building one of the NFL’s longest-running feuds. The all-time regular-season record sits at 78-71-3 in favor of the Rams, while the 49ers hold a slight edge in recent years. Both franchises have claimed Super Bowl titles, and their games consistently deliver playoff-level intensity.

The rivalry intensified when the Rams returned to Los Angeles in 2016 and hired Sean McVay in 2017. Kyle Shanahan arrived in San Francisco the same year. Their coaching chess matches have produced some of the most creative offensive football in the league.

2025 Season Series: Two Games, Two Wild Outcomes

Week 5: 49ers 26, Rams 23 (OT) — October 2, 2025

The first meeting at SoFi Stadium was a Thursday Night Football thriller. Backup quarterback Mac Jones, filling in for the injured Brock Purdy, threw for 342 yards and two touchdowns. Kendrick Bourne exploded for 10 catches and a career-high 142 receiving yards.

Matthew Stafford countered with 389 passing yards and three touchdowns for the Rams. But Eddy Pineiro’s 41-yard field goal in overtime sealed the 49ers’ victory.

Key Team Stats Comparison:

Week 10: Rams 42, 49ers 26 — November 9, 2025

The rematch at Levi’s Stadium told a different story. Stafford put on an MVP-caliber performance, throwing for 280 yards and four touchdowns with zero interceptions. He became the first quarterback in Rams franchise history to throw 4+ touchdowns in three straight games.

Mac Jones again played well for San Francisco, completing 33 of 39 passes for 319 yards, three touchdowns, and one interception. But the Rams’ defense forced two critical turnovers that turned the game.

Key Team Stats Comparison:

Complete Passing Stats: 49ers vs Los Angeles Rams

Week 10 Passing Breakdown

Stafford’s 127.1 passer rating was his highest of the 2025 season. Jones posted a 115.7 rating, marking his fourth game with a rating above 110.

Week 5 Passing Breakdown

Stafford’s 389 yards in Week 5 were his season high. Jones became the first 49ers backup quarterback to throw for 300+ yards in consecutive starts since 2013.

Rushing Stats: Ground Game Comparison

Week 10 Rushing Leaders

The Rams’ rushing attack generated 126 yards on 30 carries (4.2 average). Williams scored twice, including a 2-yard touchdown on the opening drive. The 49ers struggled to establish the run, managing just 74 yards on 21 attempts.

Week 5 Rushing Leaders

Neither team found much success on the ground in Week 5, combining for just 152 rushing yards.

Receiving Stats: Top Pass-Catchers on Both Sides

Week 10 Receiving Leaders

Kittle caught all nine of his targets, continuing his reputation as one of the NFL’s most reliable tight ends. Adams’ touchdown reception moved him past Tony Gonzalez for 8th-most receiving touchdowns in NFL history.

Week 5 Receiving Leaders

Bourne’s 142-yard performance was a career best and the defining moment of the 49ers’ overtime victory.

Defensive Stats: Turnovers and Key Stops

The Rams’ defense made the difference in Week 10, forcing two turnovers that directly led to touchdowns.

Landman’s punch-out fumble in the red zone stalled a promising 49ers drive. Forbes’ interception in the fourth quarter sealed the game.

Special Moments That Defined the 2025 Matchups

Week 5: Bourne’s Career Day and Pineiro’s Ice-Cold Kick

Kendrick Bourne’s 142 receiving yards set the tone. His 35-yard catch in overtime set up Pineiro’s game-winning 41-yard field goal. The 49ers celebrated their first overtime win since January 2023.

Week 10: Stafford’s Historic Streak and Adams’ Record

Stafford’s four-touchdown performance made him the 7th quarterback in NFL history to throw 4+ touchdowns in three consecutive games. He joined Drew Brees, Patrick Mahomes, Russell Wilson, Tom Brady, Peyton Manning, and Dan Marino. Adams’ touchdown catch moved him past Tony Gonzalez on the all-time list.

Top Players: 49ers vs Los Angeles Rams Match Player Stats Leaders

Overall Statistical Leaders (2025 Season Series)

Stafford’s 669 passing yards and 7 touchdowns across two games highlight his dominance in this rivalry. Puka Nacua’s 149 receiving yards and two scores made him Stafford’s most trusted target.

How the 49ers and Rams Match Up Historically

The Rams lead the all-time regular-season series 78-71-3. The teams are deadlocked 1-1 in the playoffs. Recent history favors San Francisco, with the 49ers winning seven of their previous nine games at SoFi Stadium.

Recent Matchup Results:

Conclusion: The Rivalry Keeps Delivering

The 49ers vs Los Angeles Rams rivalry consistently produces unforgettable football. From Stafford’s historic touchdown streak to Bourne’s career day, the 2025 season added new chapters to this storied feud. The 49ers vs Los Angeles Rams match player stats tell a story of two teams that know each other perfectly—and still find ways to surprise.

Whether you’re a fantasy football manager, a die-hard fan, or a casual observer, this rivalry rewards your attention. The next chapter arrives in 2026. Don’t miss it.